Major Responsibilities：
1.Lead exploring and development of proprietary viral vector platforms to drive pipeline development and success by optimizing all aspects of viral vector design including but not limited to yield, transgene expression, RCL/R, insertional mutagenesis, cell or target tissue-specificity, immune evasion, availability and reduced cost of viral vector manufacturing.
2.Lead establishing and conducting various assays/ models to screen and validate the vectors from safety and efficacy perspective.
Work effectively with cross-functional teams (early research, analytical development, process development, preclinical development and CMC) to support pipeline activities in an interdisciplinary and fast paced environment.
3.Provide technical leadership within the team on both lentiviral and γ-retroviral vector biology, construction, process development and manufacturing.
Lead tech transfer to CDMOs.
4.Assist in drafting, reviewing, approving, and supporting regulatory filings, including IND amendments, BLAs, and regulatory responses.
5.Work with BD team on looking for and assessing novel viral vector relevant technologies.
6.Develop and mentor a group of diverse scientists and research associates to enable cross-functional collaboration, leading innovation and career development.
Qualifications:
1.PhD in virology, immunology, cell biology or molecular biology; 6+ years of proven experience in applied virology including lentiviral and / or γ-retroviral vector development.
2.Having extensive expertise in molecular pathogenesis of viral infections, immunological response to infectious agents, and application of viral vectors for gene transfer.
3.Vast experience with viral risk assessments, viral safety tests and control strategies.
4.Extensive hands-on experience in viral vector design is required.
5.Outstanding innovative thinking and problem-solving skills.
6.Deliverables with a goal-oriented and data-driven way.
7.Ability to work under pressure and meet tight deadlines.
8.Proven track record of project or program management.
9.Experience in team management is a plus.
10.Evidence of effective bi-lingual fluency (Chinese and English) verbal and written communication skills.