Job Description: - Scientifically lead a discovery research team developing innovative ways to manufacture cell product for clinical trial. - Subject matter expert in CAR T cell process development and manufacturing. - Execute research timelines to meet program and corporate objectives. - Design， execute， and interpret process development study data to understand the mechanism-of-action and play an active role in subsequent scientific discussions to drive decisions. - Write and review protocols， SOPs， technical reports， regulatory documents， and memos to summarize experiments and investigations. - Partner with internal cross-functional team members to facilitate technical assessment， technical transfer， and IND filing. - Closely mentor scientists to further develop talent within the group. - Other duties will be assigned， as necessary.
Minimum Requirements/Qualifications: - Ph.D. in Cell Biology， Immunology， Genetic Engineering， or related discipline. - Extensive hands-on experience with CRSIPR- genome engineering in multiple cell types. - Independently design constructs and sgRNA for KO/KI through non-viral gene transfer technologies (EP， LNP) or viral transfer technologies (LVV， RVV， VLP). - Profound skills in analytical methods including but not limited to flow cytometry， real-time PCR， off-target evaluation， NGS， ddPCR. - Much experience in CAR-T， CAR-γδT， or CAR-NK cell immunotherapies， including cell culture， immune cell activation， expansion， viral transduction or /and non-viral gene transfer， in vitro ＆ in vivo characterization. - Excellent communication skills both in English and Chinese， detail-oriented organization skills， and team collaboration skills. - Strong ability to edit data， report data， present findings to management is required. - Ability to manage priorities and make decisions in a fast-paced environment to make sure deliverables are achieved in a timely fashion. - A strong track record of scientific accomplishments， including first-author publications， patent applications， and/or presentations at major national meetings， is required. - Occasional domestic or international travel required.
