工作职责:
Role

We are currently seeking an experienced scientist with or without managing capabilities to join our growing protein crystallography team based in Suzhou, China. In close collaboration with the various groups of Protein Science Platform at WuXi AppTec, we work on structural biology projects covering a wide variety of target classes to support our clients’ diverse research projects. Your main responsibilities will include the characterization and crystallization of protein-ligand complexes of both established and new targets, developing strategies for the optimization of protein crystals and performing data collection and structure determination. You will interact closely both with the protein purification and biophysics groups in Suzhou, Shanghai and Munich, Germany.

Responsibilities
61 To solve protein structures using X-ray crystallography technique to inform the interaction mode of compounds
61 To help guide the production of suitable protein for structural studies by working closely with Protein Science colleagues
61 Facilitate internal collaborations to address issues related to accessing certain protein families for structural work
61 Effectively coordinate and communicate timely results through presentations, e-mails and reports

任职资格:
Required skills
61 PhD in a structural biology with 1-5 years of postdoctoral/industrial experience in small molecule drug discovery (for Director-level, more experiences are preferred)
61 (Director-level): demonstrated accountability, management experiences, skills with accomplished milestones are required.
61 (Director-level): training staff, review and approve the data reports, coordinate the projects, arrange the resources, define the quotation structure, represent the team and platform to negotiate with the client and work with BD and PM supports, approve the final quotation, and responsible for the performances (e.g. revenue, future plans, strategies, and budget) of the platform.
61 Hands-on experience and demonstrated success of protein crystallization, optimization, data collection and crystal structure determination
61 Familiar with state-of-the-art liquid handling robotics in protein crystallization as well as mounting of protein crystals and collecting x-ray diffraction data on in-house or synchrotron radiation sources
61 Strong knowledge and understanding of biophysical methods, such as SPR, MST and DSC/DSF
61 Attention to detail, excellent troubleshooting and problem-solving skills, ability to work in a multidisciplinary, fast-paced, goal-oriented team
61 Responsible as project technical lead on multiple projects, with responsibility for project outcome and customer interaction, including developing customer relationship to grow the business
Desirable skills & Experiences
61 Experience with the crystallization of membrane proteins is a plus
61 Experience with multiple hit ID, fragment-based technologies, and assays for in vitro campaigns is preferred
61 Use of molecular biology and structure prediction analysis software
61 Basic chemistry knowledge in the area of protein-ligand interactions