岗位职责
1. 负责和监督创新药研发中药物代谢动力学(DMPK)实验动物部分的设计、执行、数据分析、撰写研究报告
2. 技术指导大, 小动物(小鼠, 大鼠, 狗，猴，兔，小型猪等)的给药（如灌胃、静脉注射、腹腔注射或皮下给药等），采血，动物解剖，动物组织釆集等动物实验操作中遇到各种问题
3. 负责非临床啮齿动物和大型动物的临床前单次给药和重复给药探索性毒理学研究方案设计, 执行, 数据分析和解释，并撰写研究报告
4. 负责实验动物组运营，管理和培训, 及组员的绩效考核；并与部门内各种功能组协同工作，按时高质量完成相关项目
5. 负责客户的实验项目，保持切实有效的沟通，及时报告研究进展。
6. 具有优良的中英文书面和口头沟通能力，良好的人际沟通和有效的领导能力。
7. 关注新技术，如实验动物科学中的新药物输送系统，并根据需要建立新的服务能力。
任职要求
1. 要求动物医学、医学，药理学， 毒理学等相关专业的硕士或博士学位，8 - 15年制药，生物技术或外包合同研究(CRO)公司工作经验。
2. 至少8年以上直接从事实验动物，药物代谢动力学，毒代动力学，***耐受剂量和剂量暴露量相关性的相关工作经验。
3. 熟练掌握药代动力学研究中的各种动物实验技术及方法。
4. 具有探索性毒理学研究的工作经验和领导能力，包括研究设计、执行、数据分析和报告撰写、以及动物毒性临床观察和临床病理（临床化学、血液学和凝血）之间的数据解释以及组织病理学结果变化的解读。
5. 具有在药物发现和临床前开发的各个阶段，创新药物的吸收、分布、代谢、排泄和毒理学方面的知识和经验。
6. 具有管理大型团队的丰富经验，具有较强的学习和解决问题的能力, 以及较强的组织、沟通、协调能力。
7. 熟悉美国食品药品监督管理局（USFDA）和国家药品监督管理局（NMPA）关于药物代谢、药代动力学, 毒代动力学, 药物单次给药和重复给药毒性研究的技术指导原则，并具有国际、国家和地方动物使用和护理法规和政策（AAALAC、IACUC, 实验动物管理委员会）的工作经验。
Responsibilities
Job responsibilities:
1. Oversee design, execution, data analysis, and report writing of in-life part of pharmacokinetics (DMPK) studies in small and large animals in drug discovery and preclinical development.
2. Technical guiding on various administration routes such as intragastric, intravenous, intraperitoneal or subcutaneous administration, blood collection, animal anatomy, tissue collection of small and large animals (mice, rats, dogs, monkeys, rabbits, min-pigs, etc.)
3. Responsible for design, execution, data analysis, date interpretation and report writing of preclinical exploratory toxicology studies in rodents and large animals.
4. Be responsible for operation, management and training of lab animal group, as well as the group members’ performance review, and cooperating with various functional groups within the department to ensure study completion with high quality on time.
5. Be responsible for project management, study progress, study tracking and efficient communication with clients.
6. Excellent written and oral communication skills in Chinese and English, good interpersonal communication and capable leadership
7. Pay attention to new technologies such as new drug delivery systems in laboratory animal science and build new service capability as needed.
Requirements
Job requirements:
1. A Ph.D. or MS degree in veterinary medicine, medicine, pharmacology, toxicology and other related disciplines with 8 - 15 year working experience in pharmaceutical and biotechnology companies or contract research organizations (CRO).
2. At least 8-year working experience directly engaged in experimental animals, pharmacokinetics, toxicokinetics, maximum tolerated dose and dose range finding studies.
3. Strong and wide lab animal experimental technical skills and experience related pharmacokinetics studies.
4. Working experience and leadership in exploratory or non-GLP toxicology studies including study design, execution, data analysis, report writing and data interpretation between clinical observation and clinical pathology (clinical chemistry, hematology and coagulation) and histopathology results.
5. Working knowledge and experience in absorption, distribution, metabolism, excretion and toxicology of new chemical entities in various stages of drug discovery and preclinical development.
6. Extensive experience in managing a large team and having strong capabilities to learn and solve problems.
7. Working knowledge with USFDA and NMPA technical guidelines on drug metabolism, pharmacokinetics and toxicokinetics, and experience with international, national and local animal use and care regulations and policies (AAALAC, IACUC, Laboratory Animal Management Committee).