Responsibilities:

JW’s world-class clinical team is seeking a talented and highly motivated Sr. Scientist (title commensurate with experience) to join our Translational Research group. In this role you will design and implement biomarker strategies to characterize the distribution, efficacy and mechanism of actions of CAR-T and TCR-T drug products in preclinical models and early clinical trials in solid tumors and malignant hematology. In addition, you will lead the translational biomarker collaboration with some of the world’s best oncology companies and JW’s biotech partners in the USA.
83 Design and implement translational strategies to characterize the solid tumor microenvironment (TME), tumor infiltration lymphocytes (TIL), and therapeutic T-cell products in order to identify potential biomarkers associated with PK and clinical outcomes
83 Design and implement biomarker strategies to elucidate the mechanisms of actions (MOA) of therapeutic T-cell products and their combinations, and to correlate these mechanisms into clinical benefits
83 Manage the collaborative activities with both JW’s international alliances and domestic vendors to generate and test biomarker hypothesis with cutting-edge assays
83 Collaborate cross-functionally with Medical Science, Clinical Operations, Bioanalysis, Preclinical Pharmacology, Process Development, and Analytical Development teams in the development and proof-of-concept of hypothesis-based clinical biomarker plans
83 Provide technical leadership in the transfer of biomarker assays to bioanalysis group for clinical trials using a broad range of technologies
83 Continuously evaluate new technologies for clinical immune-oncology and T cell functional characterization while implementing and refining translational and biomarker strategies to maintain JW on the cutting edge of CAR-T and TCR-T cell-therapies.

Qualification:
61 Ph.D. in immunology or similar discipline with 1+ years of directly relevant experience; Or MS with at least 3+ years in immuno-oncology biomarkers in an industry setting; Candidates without a PhD will be considered if they have commensurate experience
61 Hands on experience in MOA based biomarker identification and clinical implementation in immuno-oncology is preferred; experience with cell therapies is highly desirable
61 Expertise in human T cell biology, in vitro and in vivo functional assays utilizing human T cells; experience with CAR-T, TCR-T, or a related cell therapy platform is highly desired
61 Experience in biomarker assays using a broad range of technologies including ligand binding immunoassays, assays of T cell function, multi-parametric flow cytometry, multiplex IHC and/or ISH assays, real-time PCR and next generation sequence analysis
61 Highly effective collaboration in a matrix environment, written/verbal communication in Chinese and English, and interpersonal skills
61 Can-do attitude and ambition to be the best in the field of cancer cell therapy